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April 13th, 2009
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Filed under:
Build Muscle, bodybuilding supplements
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New research points to possible treatments for muscle wasting disorders offers exciting news because FHL1 appears to modulate muscle mass and strength enhancement. The protein partners with and activates the transcription factor, NFATc1. Encouraging this partnership might provide a possible treatment for muscle wasting disorders. The article will appear in the December 15, 2008 issue of The Journal of Cell Biology (JCB). Mutations in FHL1 are present in several myopathies, including reducing-body myopathy (RBM), but until now, both the molecular mechanisms causing the disease, and the regular function of FHL1 in healthy tissue, remained unknown. To address this, Cowling et al. overexpressed FHL1 in both transgenic mice and cultured myoblasts. The mice developed skeletal muscle hypertrophy, and showed increased strength and endurance. Overexpression in myoblasts also increased cell fusion, resulting in hypertrophic myotubes. These phenotypes are similar to those caused by the calcineurin/NFAT pathway and, indeed, inhibiting calcineurin blocked the effects of FHL1 overexpression in vitro. The authors showed that FHL1 binds to and enhances the transcriptional activity of NFATc1 in vitro and in vivo. So what goes wrong when FHL1 is mutated? In RBM, mutant FHL1 accumulates in cytoplasmic aggregates called reducing bodies, probably as a result of misfolding. When these mutants were expressed in cultured myoblasts, they also aggregated, and did not induce hypertrophy. Cowling and colleagues found that NFATc1 was sequestered to the aggregates, and was therefore unable to activate its target genes. ———————————- Contact: Rita Sullivan Cowling, B.S., J Cell Biol. 2008 Dec 15;183(6):1033-48 |
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4 Responses to “How to build muscle mass with FHL1”
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May 5th, 2009 at 2:53 am
[...] How to Build Muscle and Increase Strenght With FHL1 Amino Acids that Tell Muscle Cells to Build Protien Decrease Fat and Over Muscle with Growth Factor [...]
May 5th, 2009 at 3:23 am
[...] How to Build Muscle and Increase Strenght With FHL1 Amino Acids that Tell Muscle Cells to Build Protien Decrease Fat and Over Muscle with Growth Factor [...]
May 6th, 2009 at 10:42 pm
[...] How to Build Muscle and Increase Strenght With FHL1 Amino Acids that Tell Muscle Cells to Build Protien Decrease Fat and Over Muscle with Growth FactorIn many HIV-infected individuals with prior weight loss, the failure to regain weight and lean tissue is at least in part the consequence of inadequate protein intake or ingestion of a poor-quality protein rather than total caloric intake. Dietary sources of protein are presumably inadequate to meet the high metabolic needs caused by HIV infection. To achieve a target protein intake in the range (1.5 to 2.0 g/kg/day) demonstrated in other catabolic diseases necessary to achieve positive nitrogen balance and to generate substantial anabolic effects. [...]
May 7th, 2009 at 4:18 am
[...] How to Build Muscle and Increase Strenght With FHL1 Amino Acids that Tell Muscle Cells to Build Protien Decrease Fat and Over Muscle with Growth Factor [...]